Goodness-of-fit Test for a Locus Showing Departure from HWE


Number of wild-type patients
Number of of heterozygous patients
Number of susceptible homozygous patients
Number of wild-type controls
Number of heterozygous controls
Number of susceptible homozygous controls
Population prevelence

 


 
 
This tool inputs the genotype counts in affected cases and unaffected controls that show a departure from HWE
(cases only show a departure from HWE, controls only show a departure from HWE, or both cases and controls 
show departures from HWE )  and outputs the best-fit genetic disease model to the observed data.  If the  chi^2 
test with 2 d.f. yields a p-value below the specified threshold, the disease model shows a significantly poor fit to 
the observed data.